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Источник : Molecular Biology Re ... ✕Базы данных : Scopus ✕
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Exploring of the ameliorative effects of Nerium (Nerium oleander L.) ethanolic flower extract in streptozotocin induced diabetic rats via biochemical, histological and molecular aspects

Ali ASLAN

Background: Nerium oleander L. is ethnopharmacologically used for diabetes. Our aim was to investigate the ameliorative effects of ethanolic Nerium flower extract (NFE) in STZ-induced diabetic rats. Methods: Seven random groups including control group, NFE group (50 mg/kg), diabetic group, glibenclamide group and NFE treated groups (25 mg/kg, 75 mg/kg, and 225 mg/kg) were composed of forty-nine rats. Blood glucose level, glycated hemoglobin (HbA1c), insulin level, liver damage parameters and lipid profile parameters were investigated. Antioxidant defense system enzyme activities and reduced gl ...Более

Статья 2023 Fen Fakültesi Molecular Biology Reports50 ( 5 ) 23 Просмотры
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DNA fingerprinting and assessment of some physiological changes in Al-induced Bryophyllum daigremontianum clones

İbrahim İlker ÖZYİĞİT

Aluminum (Al) is one of the most important stress factors that reduce plant productivity in acidic soils. Present work thereby analyzed Al-induced genomic alterations in Bryophyllum daigremontianum clones using RAPD and ISSR markers, and investigated responding changes in photosynthetic pigment (chlorophyll a, b, a/b, total chlorophyll and carotenoid) contents and total soluble protein amounts in plant leaves. The main reason for the use of bulbiferous spurs originated clone plants was to increase reliability and acceptability of RAPD and ISSR techniques in DNA fingerprinting. Raised 40 clone ...Более

Статья 2019 Fen Fakültesi Molecular Biology Reports46 ( 3 ) 65 Просмотры
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Prophylactic effect of myricetin and apigenin against lipopolysaccharide-induced acute liver injury

Ali ASLAN

Background Liver has an important role in the initiation and progression of multiple organ failure that occurs in sepsis. Many natural active substances can be used to reduce the liver injury caused by sepsis. For this aim, the effects of myricetin and apigenin on mice model of acute liver injury was evaluated in this study. Methods and results Thirty-six mice were randomly divided into six groups as; control, lipopolysaccharide (LPS) (5 mg/kg), LPS myricetin (100 mg/kg), LPS myricetin (200 mg/kg), LPS apigenin (100 mg/kg), and LPS apigenin (200 mg/kg) groups. Myricetin and apigenin were admin ...Более

Статья 2021 Fen Fakültesi Molecular Biology Reports48 ( 9 ) 47 Просмотры
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Gene transfer to plants by electroporation: methods and applications

İbrahim İlker ÖZYİĞİT

Developing gene transfer technologies enables the genetic manipulation of the living organisms more efficiently. The methods used for gene transfer fall into two main categories; natural and artificial transformation. The natural methods include the conjugation, transposition, bacterial transformation as well as phage and retroviral transductions, contain the physical methods whereas the artificial methods can physically alter and transfer genes from one to another organisms

Обзор 2020 Fen Fakültesi Molecular Biology Reports47 ( 4 ) 55 Просмотры
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Particle bombardment technology and its applications in plants

İbrahim İlker ÖZYİĞİT

Particle bombardment, or biolistics, has emerged as an excellent alternative approach for plant genetic transformation which circumvents the limitations of Agrobacterium-mediated genetic transformation. The method has no biological constraints and can transform a wide range of plant species. Besides, it has been the most efficient way to achieve organelle transformation (for both chloroplasts and mitochondria) so far. Along with the recent advances in genome editing technologies, conventional gene delivery tools are now being repurposed to deliver targeted gene editing reagents into the plants ...Более

Обзор 2020 Fen Fakültesi Molecular Biology Reports47 ( 12 ) 86 Просмотры
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