This study aimed to determine the potential toxicological effects of carbon nanotubes (CNTs), their modifications with ethylenediamine (ED) and boric acid (BA) on aquatic organisms. Specifically, the research focused on the morphological, physiological, and histopathological-immuno-histochemical responses in zebrafish (Danio rerio) embryos and larvae, via applying different concentrations of CNTs, CNT-ED, and CNT-ED-BA (Control, 5, 10, and 20 mg/L). The results indicated that 20 mg/L CNT nanoparticles were toxic to zebrafish larvae, with mortality rates increasing with CNT and CNT-ED concentrations, reaching 36.7 at the highest CNT concentration. The highest dose caused considerable degeneration, necrosis, DNA damage, and apoptosis, as evidenced by histopathological and immunohistochemical tests. In contrast, despite their high concentration, CNT-ED-BA nanoparticles exhibited low toxicity. Behavioral studies revealed that CNT and CNT-ED nanoparticles had a more significant impact on sensory-motor functions compared to CNT-ED-BA nanoparticles. These findings suggest that modifying the nanosurface with boric acid, resulting in boramidic acid, can reduce the toxicity induced by CNT and CNT-ED.
Keyword: apoptosis; carbon nanoparticles; danio rerio; DNA damage; morphological abnormality
Yayın Adı (dc.title) | Effect of boramidic acid modified carbon nanotubes on neurological, morphological and physiological responses of zebrafish (Danio rerio) embryos and larvae |
Yazar/lar (dc.contributor.yazarlar) | Aybek Yiğit, Mine Köktürk, Serkan Yıldırım, Dilek Nazli, Metin Kılıççıoğlu, Ayse Sahin, Muhammed Atamanalp, Gunes Ozhan, Nurettin Menges, Gonca Alak |
Yayın Türü (dc.type) | Makale |
Dil (dc.language) | İngilizce |
Yayımlanma Yılı (dc.date.issued) | 2024 |
Ulusal/Uluslararası (dc.identifier.ulusaluluslararasi) | Uluslararası |
Kaynak (dc.relation.journal) | Science of The Total Environment |
Cilt/Sayı (dc.identifier.volume) | 947 |
Sayfa (dc.identifier.startpage) | Article Number: 174614 |
ISSN/ISBN (dc.identifier.issn) | ISSN: 0048-9697; Online ISSN: 1879-1026 |
Yayıncı (dc.publisher) | Elsevier |
Veri Tabanları (dc.contributor.veritaban) | Web of Science Core Collection |
Veri Tabanları (dc.contributor.veritaban) | Sciencedirect |
Veri Tabanları (dc.contributor.veritaban) | Scopus |
İndex Türü (dc.identifier.index) | SCI Expanded |
İndex Türü (dc.identifier.index) | Scopus |
Etki Faktörü (dc.identifier.etkifaktoru) | 8,2 / 2023-WOS / Son 5 yıl: 8,6 |
Özet (dc.description.abstract) | This study aimed to determine the potential toxicological effects of carbon nanotubes (CNTs), their modifications with ethylenediamine (ED) and boric acid (BA) on aquatic organisms. Specifically, the research focused on the morphological, physiological, and histopathological-immuno-histochemical responses in zebrafish (Danio rerio) embryos and larvae, via applying different concentrations of CNTs, CNT-ED, and CNT-ED-BA (Control, 5, 10, and 20 mg/L). The results indicated that 20 mg/L CNT nanoparticles were toxic to zebrafish larvae, with mortality rates increasing with CNT and CNT-ED concentrations, reaching 36.7 at the highest CNT concentration. The highest dose caused considerable degeneration, necrosis, DNA damage, and apoptosis, as evidenced by histopathological and immunohistochemical tests. In contrast, despite their high concentration, CNT-ED-BA nanoparticles exhibited low toxicity. Behavioral studies revealed that CNT and CNT-ED nanoparticles had a more significant impact on sensory-motor functions compared to CNT-ED-BA nanoparticles. These findings suggest that modifying the nanosurface with boric acid, resulting in boramidic acid, can reduce the toxicity induced by CNT and CNT-ED. |
Özet (dc.description.abstract) | Keyword: apoptosis; carbon nanoparticles; danio rerio; DNA damage; morphological abnormality |
URL (dc.rights) | https://www.sciencedirect.com/science/article/abs/pii/S0048969724047636 |
DOI (dc.identifier.doi) | 10.1016/j.scitotenv.2024.174614 |
Fakültesi / Enstitütü (dc.identifier.fakulte) | Veteriner Fakültesi |
Bölümü (dc.identifier.bolum) | Veteriner |
Kurumdaki Yazar/lar (dc.contributor.author) | Serkan YILDIRIM |
Kayıt No (dc.identifier.kayitno) | BL5FA1DF75 |
Kayıt Giriş Tarihi (dc.date.available) | 2024-07-18 |
Not (Yayımlanma Yılı) (dc.identifier.notyayinyili) | October 2024 |
Wos No (dc.identifier.wos) | WOS:001269423800001 |
Konu Başlıkları (dc.subject) | apoptosis |
Konu Başlıkları (dc.subject) | carbon nanoparticles |
Konu Başlıkları (dc.subject) | danio rerio |
Konu Başlıkları (dc.subject) | DNA damage |
Konu Başlıkları (dc.subject) | morphological abnormality |