For the first time in the literature, p (PmO), p (LO) and p (RO) organo-particles were synthesized from Peppermint oil, Lemon oil and Rose oil. Of the organo-particles L-929 cell line viability/cytotoxicity and anticancer effect against Capan-1 pancreatic cancer cell line were investigated. p (PmO), p (LO) and p (RO) organo-particles were featured by thermogravimetry (TGA), Fourier Transform Infrared Spectroscopy (FTIR), Scanning electron microscope (SEM), Particle size (DLS), and particle charge (zeta potential, Zeta) analyses. Antioxidant, biocompatible, and antimicrobial activities and in vitro cytotoxicity specialties were investigated. In studies on Capan-1 and L-929 cell lines, it was observed that p (PmO), p (LO) and p (RO) organo-particles were effective on L-929 fibroblast cell line on Capan-1 pancreatic cancer cell line. In addition, it was observed that p (PmO), p (LO) and p (RO) organo-particles were not toxic in L-929 cell lines at high doses. When the Capan-1 cell line MTT analysis results of p (PmO), p (LO) and p (RO) organo-particles were examined, a difference was observed between cell viability rates and apoptosis and necrosis values. The highest apoptosis rate was observed in the p (RO) organo particle.
Keyword: capan-1; L-929; lemon oil; organo particle; peppermint oil; rosa oil
Publication Name (dc.title) | Characterization of p(PmO), p(LO) and p(RO) organoparticles, their bioactivity properties and their effect on pancreatic cancer Capan-1 cell |
Author/s (dc.contributor.yazarlar) | Duygu Alpaslan, Abdullah Turan, Tuba Ersen Dudu, Busra Moran Bozer, Nahit Aktas, Mustafa Turk |
Publication type (dc.type) | Makale |
Language (dc.language) | İngilizce |
Publication year (dc.date.issued) | 2023 |
National/International (dc.identifier.ulusaluluslararasi) | Uluslararası |
Source (dc.relation.journal) | Materials Chemistry and Physics |
Volume/Issue (dc.identifier.volume) | 305 |
Page (dc.identifier.startpage) | Article Number: 127871 |
ISSN/ISBN (dc.identifier.issn) | ISSN: 0254-0584; Online ISSN: 1879-3312 |
Publisher (dc.publisher) | Elsevier |
Databases (dc.contributor.veritaban) | Web of Science Core Collection |
Databases (dc.contributor.veritaban) | Sciencedirect |
Databases (dc.contributor.veritaban) | Scopus |
Index Type (dc.identifier.index) | SCI Expanded |
Index Type (dc.identifier.index) | Scopus |
Impact Factor (dc.identifier.etkifaktoru) | 4,6 / 2022-WOS / 5 Year: 4,1 |
Abstract (dc.description.abstract) | For the first time in the literature, p (PmO), p (LO) and p (RO) organo-particles were synthesized from Peppermint oil, Lemon oil and Rose oil. Of the organo-particles L-929 cell line viability/cytotoxicity and anticancer effect against Capan-1 pancreatic cancer cell line were investigated. p (PmO), p (LO) and p (RO) organo-particles were featured by thermogravimetry (TGA), Fourier Transform Infrared Spectroscopy (FTIR), Scanning electron microscope (SEM), Particle size (DLS), and particle charge (zeta potential, Zeta) analyses. Antioxidant, biocompatible, and antimicrobial activities and in vitro cytotoxicity specialties were investigated. In studies on Capan-1 and L-929 cell lines, it was observed that p (PmO), p (LO) and p (RO) organo-particles were effective on L-929 fibroblast cell line on Capan-1 pancreatic cancer cell line. In addition, it was observed that p (PmO), p (LO) and p (RO) organo-particles were not toxic in L-929 cell lines at high doses. When the Capan-1 cell line MTT analysis results of p (PmO), p (LO) and p (RO) organo-particles were examined, a difference was observed between cell viability rates and apoptosis and necrosis values. The highest apoptosis rate was observed in the p (RO) organo particle. |
Abstract (dc.description.abstract) | Keyword: capan-1; L-929; lemon oil; organo particle; peppermint oil; rosa oil |
URL (dc.rights) | https://www.sciencedirect.com/science/article/abs/pii/S0254058423005795 |
DOI (dc.identifier.doi) | 10.1016/j.matchemphys.2023.127871 |
Faculty / Institute (dc.identifier.fakulte) | Mühendislik Fakültesi |
Department (dc.identifier.bolum) | Kimya Mühendisliği Bölümü |
Author(s) in the Institution (dc.contributor.author) | Nahit AKTAŞ |
Kayıt No (dc.identifier.kayitno) | BL1405FBF2 |
Record Add Date (dc.date.available) | 2023-07-05 |
Notes (Publication year) (dc.identifier.notyayinyili) | September 2023 |
Wos No (dc.identifier.wos) | WOS:001017132100001 |
Subject Headings (dc.subject) | capan-1 |
Subject Headings (dc.subject) | L-929 |
Subject Headings (dc.subject) | lemon oil |
Subject Headings (dc.subject) | organo particle |
Subject Headings (dc.subject) | peppermint oil |
Subject Headings (dc.subject) | rosa oil |