A nanostructured silver-aniline modified pencil electrode obtained by applying experimental design and optimization was developed for the differential pulse stripping voltammetric quantification of acetaminophen in the pharmaceutical products, tablet and syrup. The electrode development process was performed by the modification of PGE with aniline using CV procedure and the reduction of silver nanoparticle on the polyaniline modified PGE. As a result, a new electrode system consisting of a nanostructured silver-polyaniline modified pencil graphite electrode (AgNS-PA-PGE) was obtained to reach a well-defined and higher peak current for the analysis of the related drug. The calibration curve was found linear in the range of 5 × 10−8–8 × 10−7 M for acetaminophen. The validity and applicability of the proposed voltammetric method was tested by analyzing independent validation samples. It was observed that the proposed voltammetric approach for the real tablet and syrup samples gave successful analysis results.
Название публикации (dc.title) | Determination of Acetaminophen in Commercial Formulations Using Silver Nanostructured Aniline Modified Pencil Graphite Electrode |
Автор/ы (dc.contributor.yazarlar) | Remziye Güzel, Haslet Ekşi, Erdal Dinç, Ali Osman Solak |
Вид публикации (dc.type) | Makale |
Язык (dc.language) | İngilizce |
Год публикации (dc.date.issued) | 2013 |
Национальный/Международный (dc.identifier.ulusaluluslararasi) | Uluslararası |
Источник (dc.relation.journal) | Journal of The Electrochemical Society |
Номер (dc.identifier.issue) | 8 |
Том/№ (dc.identifier.volume) | 160 |
Страница (dc.identifier.startpage) | B119-B124 |
ISSN/ISBN (dc.identifier.issn) | ISSN: 0013-4651; Online ISSN: 1945-7111 |
Издатель (dc.publisher) | IOP Publishing |
Базы данных (dc.contributor.veritaban) | Web of Science Core Collection |
Базы данных (dc.contributor.veritaban) | Scopus |
Базы данных (dc.contributor.veritaban) | IOP Science |
Вид индекса (dc.identifier.index) | SCI Expanded |
Вид индекса (dc.identifier.index) | Scopus |
Импакт-фактор (dc.identifier.etkifaktoru) | 3,662 / 2017-WOS / 5 Year: 3,52 |
Резюме (dc.description.abstract) | A nanostructured silver-aniline modified pencil electrode obtained by applying experimental design and optimization was developed for the differential pulse stripping voltammetric quantification of acetaminophen in the pharmaceutical products, tablet and syrup. The electrode development process was performed by the modification of PGE with aniline using CV procedure and the reduction of silver nanoparticle on the polyaniline modified PGE. As a result, a new electrode system consisting of a nanostructured silver-polyaniline modified pencil graphite electrode (AgNS-PA-PGE) was obtained to reach a well-defined and higher peak current for the analysis of the related drug. The calibration curve was found linear in the range of 5 × 10−8–8 × 10−7 M for acetaminophen. The validity and applicability of the proposed voltammetric method was tested by analyzing independent validation samples. It was observed that the proposed voltammetric approach for the real tablet and syrup samples gave successful analysis results. |
URL (dc.rights) | https://iopscience.iop.org/article/10.1149/2.102308jes |
DOI (dc.identifier.doi) | 10.1149/2.102308jes |
Факультет / Институт (dc.identifier.fakulte) | Mühendislik Fakültesi |
Кафедра (dc.identifier.bolum) | Kimya Mühendisliği Bölümü |
Автор(ы) в учреждении (dc.contributor.author) | Ali Osman SOLAK |
№ регистрации (dc.identifier.kayitno) | BLDA7C6379 |
Дата регистрации (dc.date.available) | 2016-03-17 |
Заметка (Год публикации) (dc.identifier.notyayinyili) | 2013 |
Wos No (dc.identifier.wos) | WOS:000324810000052 |
Тематический рубрикатор (dc.subject) | voltammetric determination |
Тематический рубрикатор (dc.subject) | electrochemical oxidation |
Тематический рубрикатор (dc.subject) | paracetamol |
Тематический рубрикатор (dc.subject) | nanoparticles |
Тематический рубрикатор (dc.subject) | polyaniline |
Тематический рубрикатор (dc.subject) | behavior |
Тематический рубрикатор (dc.subject) | DNA |