In this study, gold nanoparticles (AuNPs) with the diameters of maximum 25 nm were self-assembled onto the surfaces of p-aminothiophenol functionalized graphene oxide (ATPGO) sheets simply by mixing their aqueous dispersions. The prepared graphene oxide (GO), ATPGO and AuNPs–ATPGO composites were characterized by a transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), reflection–absorption infrared spectroscopy (RAIRS), the X-ray diffraction (XRD) method and Raman spectroscopy. The electrochemical determination of quercetin (QR) has been studied using square wave voltammetry (SWV) on glassy carbon electrode (GCE) modified with AuNPs–ATPGO composite (AuNPs–ATPGO/GCE). QR gave rise to a single oxidation peak in the potential interval from 200 to 600 mV in 0.1 M acetate buffer (pH 5.5). The well-defined peaks were observed at the optimized instrumental parameters for SWV such as frequency, amplitude and potential increments. The developed method was validated according to the ICH guideline and found to be linear, sensitive, specific, precise and accurate. The linearity range of QR was 1.0 × 10−12–1.0 × 10−11 M with the detection limit (S/N = 3) of 3.0 × 10−13 M under optimum conditions. The validated method was applied successfully for the determination of QR in pharmaceutical preparations. -
Keywords: Quercetin; Graphene oxide; Gold nanoparticles; Square wave voltammetry; Validation
Название публикации (dc.title) | A novel voltammetric sensor based on p-aminothiophenol functionalized graphene oxide/gold nanoparticles for determining quercetin in the presence of ascorbic acid |
Автор/ы (dc.contributor.yazarlar) | Mehmet Lütfi Yola, Necip Atar, Zafer Üstündağ, Ali Osman Solak |
Вид публикации (dc.type) | Makale |
Язык (dc.language) | İngilizce |
Год публикации (dc.date.issued) | 2013 |
Национальный/Международный (dc.identifier.ulusaluluslararasi) | Uluslararası |
Источник (dc.relation.journal) | Journal of Electroanalytical Chemistry |
Том/№ (dc.identifier.volume) | 698 |
Страница (dc.identifier.startpage) | 9–16 |
ISSN/ISBN (dc.identifier.issn) | ISSN: 1572-6657 |
Издатель (dc.publisher) | Elsevier |
Базы данных (dc.contributor.veritaban) | Web of Science Core Collection |
Базы данных (dc.contributor.veritaban) | Sciencedirect |
Базы данных (dc.contributor.veritaban) | Scopus |
Вид индекса (dc.identifier.index) | SCI Expanded |
Вид индекса (dc.identifier.index) | Scopus |
Импакт-фактор (dc.identifier.etkifaktoru) | 3,253 / 2017-WOS / 5 Year: 2,948 |
Резюме (dc.description.abstract) | In this study, gold nanoparticles (AuNPs) with the diameters of maximum 25 nm were self-assembled onto the surfaces of p-aminothiophenol functionalized graphene oxide (ATPGO) sheets simply by mixing their aqueous dispersions. The prepared graphene oxide (GO), ATPGO and AuNPs–ATPGO composites were characterized by a transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), reflection–absorption infrared spectroscopy (RAIRS), the X-ray diffraction (XRD) method and Raman spectroscopy. The electrochemical determination of quercetin (QR) has been studied using square wave voltammetry (SWV) on glassy carbon electrode (GCE) modified with AuNPs–ATPGO composite (AuNPs–ATPGO/GCE). QR gave rise to a single oxidation peak in the potential interval from 200 to 600 mV in 0.1 M acetate buffer (pH 5.5). The well-defined peaks were observed at the optimized instrumental parameters for SWV such as frequency, amplitude and potential increments. The developed method was validated according to the ICH guideline and found to be linear, sensitive, specific, precise and accurate. The linearity range of QR was 1.0 × 10−12–1.0 × 10−11 M with the detection limit (S/N = 3) of 3.0 × 10−13 M under optimum conditions. The validated method was applied successfully for the determination of QR in pharmaceutical preparations. - |
Резюме (dc.description.abstract) | Keywords: Quercetin; Graphene oxide; Gold nanoparticles; Square wave voltammetry; Validation |
URL (dc.rights) | http://www.sciencedirect.com/science/article/pii/S157266571300146X |
DOI (dc.identifier.doi) | 10.1016/j.jelechem.2013.03.016 |
Факультет / Институт (dc.identifier.fakulte) | Mühendislik Fakültesi |
Кафедра (dc.identifier.bolum) | Kimya Mühendisliği Bölümü |
Автор(ы) в учреждении (dc.contributor.author) | Ali Osman SOLAK |
№ регистрации (dc.identifier.kayitno) | BL5D4C2FEB |
Дата регистрации (dc.date.available) | 2016-03-03 |
Заметка (Год публикации) (dc.identifier.notyayinyili) | June 2013 |
Wos No (dc.identifier.wos) | WOS:000319957200002 |
Тематический рубрикатор (dc.subject) | quercetin |
Тематический рубрикатор (dc.subject) | graphene oxide |
Тематический рубрикатор (dc.subject) | gold nanoparticles |
Тематический рубрикатор (dc.subject) | square wave voltammetry |
Тематический рубрикатор (dc.subject) | validation |