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Ovarian cancer is a gynecological disease causing many deaths among women around the world. Carbohydrate antigen 125 (CA-125) is a single biomarker known to be a tumor marker of ovarian cancer. CA-125 is widely used to monitor the treatment process, recurrences, and for the detection of ovarian cancer. Herein, organo-hydrogels were prepared in order to detect CA-125 sensitively in serum medium with electrochemical methods. Organo-hydrogels were obtained by the free radical polymerization reaction using agar and glycerol with varying proportions of sweet almond oil using methylene bisacrylamide ...More
Organo-hydrogels were synthesized by using free radical polymerization in the emulsion technique, using agar, glycerol, sesame oil, ammonium persulfate as initiator and N,N'-methylene bisacrylamide or glutaraldehyde as crosslinker. Swelling behaviors, blood compatibility, antioxidant and properties of the organo-hydrogels were investigated thoroughly. The highest swelling value was seen in organo-hydrogel synthesized with the N,N'-methylene bisacrylamide crosslinker containing 0.1 ml of sesame oil. Moreover, drug release behaviors of organo-hydrogels were studied as paracetamol and carboplatin ...More
The very recent Covid-19 pandemic has made the need to understand biocompatible polymers as support material in drug delivery systems and controlled release clearer, especially for organo-hydrogels. This study aims to synthesize various new polymeric materials called gels, hydrogels, and organo-hydrogels according to the monomer used and to investigate their use as drug release systems. The agar-glycerol (AG) pair was used to synthesize the polymers, N, N, methylene bisacrylamide (MBA, m) and glutaraldehyde (GA, g) were used as cross-linkers and peppermint oil (PmO) was included to obtain the ...More
The aim of this study was to synthesize organo-hydrogels, by using agar, glycerol and different amounts of castor oil in one step, with biocompatible, blood-compatible and antioxidant properties using a new approach to the synthesis of smart polymers. Then, the target was to investigate the applicability of these organo-hydrogels as a drug release system. In the synthesis of organo-hydrogels, crosslinking was achieved with MBA or GA reagent and the redox polymerization technique was applied in the emulsion medium. The swelling behaviors of organo-hydrogels, which were synthesized using differe ...More
In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organo-hydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (Wu et al. in J Mol Struct 882:107-115, 2008). Organo-hydrogels, which contained Agar, Glycerol and different amounts of Sweet Almond oil, were synthesized via the free-radical polymerization reaction with emulsion technique using glutaraldehyde or methylene bis acrylamide crosslinkers. Then, the degree of swelling, bond structures, blood compatibility and antioxidant properties of the synthesized organo-hydro ...More
In this study, six different organo-hydrogel containing Agar-Glycerol (AG) based Coconut Oil (CnO) were synthesized using different crosslinkers to ensure the controlled release of D-3 Vitamine and 5-Fluorouracil (5-Flu). Synthesized organo-hydrogels were characterized by FT-IR, Afterwards, swelling behaviors were investigated in ethanol, acetone, ethanol/ID water (1:1), acetone /ID water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. Th ...More
In this study, six different organo-hydrogels containing agar-glycerol (AG)-based garlic oil (GO) were synthesized using two different crosslinkers (N,N, methylenebisacrylamide (MBA), glutaraldehyde (GA)) to ensure the controlled release of ceftriaxone (Ce) and carboplatin (Cp). Synthesized organo-hydrogels were characterized by FT-IR. Afterward, swelling behaviors were investigated in DI, tap water, ethanol, acetone, ethanol/DI water (1:1), acetone/DI water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels hav ...More
Agar and Glycerol (AG) based Organo-hydrogels containing different cross-linkers and different amounts of Onion Oil were prepared in order to examine the in vitro release of the antibiotic drug Ceftriaxone and the anti-carcinogenic drug Carboplatin. At preparation of the organo-hydrogels was used free radical polymerization technique in the emulsion media. As a control group, Agar-Glycerol (AG) gel and Agar-Glycerol (p (AG-m) and p (AG-g)) hydrogels were synthesized. When balance swelling rates of organo-hydrogels were examined, different swelling behaviors were observed in different solvent e ...More
In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organohydrogels containing pH-sensitive Agar (A), Glycerol (G), Thyme Oil (TO). The novel organo-hydrogels containing TO were prepared in an emulsion media by the free-radical polymerization and crosslinking reactions among Agar (A), Glycerol (G), TO, N, N, methylenebisacrylamide (MBA) or glutaraldehyde (GA) reagent. Swelling ability (ethanol, acetone, ethanol/ID water (1:1), acetone/ID water (1:1) and gasoline environments and different pH), Fourier Transform Infrared Spectroscopy (FTIR) a ...More