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Index Type : SCI Expanded ✕Subject Headings : agar ✕
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Synthesis and characterization of novel organo-hydrogel based agar, glycerol and peppermint oil as a natural drug carrier/release material

Nahit AKTAŞ

The very recent Covid-19 pandemic has made the need to understand biocompatible polymers as support material in drug delivery systems and controlled release clearer, especially for organo-hydrogels. This study aims to synthesize various new polymeric materials called gels, hydrogels, and organo-hydrogels according to the monomer used and to investigate their use as drug release systems. The agar-glycerol (AG) pair was used to synthesize the polymers, N, N, methylene bisacrylamide (MBA, m) and glutaraldehyde (GA, g) were used as cross-linkers and peppermint oil (PmO) was included to obtain the ...More

Article 2021 Mühendislik Fakültesi Materials Science and Engineering: C - Materials For Biological Applications118 107 Views
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Evaluation of poly(agar-co-glycerol-co-castor oil) organo-hydrogel as a controlled release system carrier support material

Nahit AKTAŞ

The aim of this study was to synthesize organo-hydrogels, by using agar, glycerol and different amounts of castor oil in one step, with biocompatible, blood-compatible and antioxidant properties using a new approach to the synthesis of smart polymers. Then, the target was to investigate the applicability of these organo-hydrogels as a drug release system. In the synthesis of organo-hydrogels, crosslinking was achieved with MBA or GA reagent and the redox polymerization technique was applied in the emulsion medium. The swelling behaviors of organo-hydrogels, which were synthesized using differe ...More

Article 2021 Mühendislik Fakültesi Polymer Bulletin79 ( 8 ) 58 Views
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Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material

Nahit AKTAŞ

In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organo-hydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (Wu et al. in J Mol Struct 882:107-115, 2008). Organo-hydrogels, which contained Agar, Glycerol and different amounts of Sweet Almond oil, were synthesized via the free-radical polymerization reaction with emulsion technique using glutaraldehyde or methylene bis acrylamide crosslinkers. Then, the degree of swelling, bond structures, blood compatibility and antioxidant properties of the synthesized organo-hydro ...More

Article 2021 Mühendislik Fakültesi Journal of Polymers and the Environment30 ( 2 ) 133 Views
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Use of Coconut Oil-Based Organo-Hydrogels in Pharmaceutical Applications

Nahit AKTAŞ

In this study, six different organo-hydrogel containing Agar-Glycerol (AG) based Coconut Oil (CnO) were synthesized using different crosslinkers to ensure the controlled release of D-3 Vitamine and 5-Fluorouracil (5-Flu). Synthesized organo-hydrogels were characterized by FT-IR, Afterwards, swelling behaviors were investigated in ethanol, acetone, ethanol/ID water (1:1), acetone /ID water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. Th ...More

Article 2021 Mühendislik Fakültesi Journal of Polymers and the Environment30 ( 2 ) 127 Views
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A garlic oil-based organo-hydrogel for use in pH-sensitive drug release

Nahit AKTAŞ

In this study, six different organo-hydrogels containing agar-glycerol (AG)-based garlic oil (GO) were synthesized using two different crosslinkers (N,N, methylenebisacrylamide (MBA), glutaraldehyde (GA)) to ensure the controlled release of ceftriaxone (Ce) and carboplatin (Cp). Synthesized organo-hydrogels were characterized by FT-IR. Afterward, swelling behaviors were investigated in DI, tap water, ethanol, acetone, ethanol/DI water (1:1), acetone/DI water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels hav ...More

Article 2021 Mühendislik Fakültesi Chemical Papers75 ( 11 ) 75 Views
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Development of onion oil-based organo-hydrogel for drug delivery material

Nahit AKTAŞ

Agar and Glycerol (AG) based Organo-hydrogels containing different cross-linkers and different amounts of Onion Oil were prepared in order to examine the in vitro release of the antibiotic drug Ceftriaxone and the anti-carcinogenic drug Carboplatin. At preparation of the organo-hydrogels was used free radical polymerization technique in the emulsion media. As a control group, Agar-Glycerol (AG) gel and Agar-Glycerol (p (AG-m) and p (AG-g)) hydrogels were synthesized. When balance swelling rates of organo-hydrogels were examined, different swelling behaviors were observed in different solvent e ...More

Article 2021 Mühendislik Fakültesi Journal of Dispersion Science and Technology44 ( 5 ) 69 Views
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