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Publisher : Springer ✕Researcher : Ali ASLAN ✕
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Prof. Dr. Ali ASLANFen Fakültesi
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Exploring of the ameliorative effects of Nerium (Nerium oleander L.) ethanolic flower extract in streptozotocin induced diabetic rats via biochemical, histological and molecular aspects

Ali ASLAN

Background: Nerium oleander L. is ethnopharmacologically used for diabetes. Our aim was to investigate the ameliorative effects of ethanolic Nerium flower extract (NFE) in STZ-induced diabetic rats. Methods: Seven random groups including control group, NFE group (50 mg/kg), diabetic group, glibenclamide group and NFE treated groups (25 mg/kg, 75 mg/kg, and 225 mg/kg) were composed of forty-nine rats. Blood glucose level, glycated hemoglobin (HbA1c), insulin level, liver damage parameters and lipid profile parameters were investigated. Antioxidant defense system enzyme activities and reduced gl ...More

Article 2023 Fen Fakültesi Molecular Biology Reports50 ( 5 ) 23 Views
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Evaluation of the biological activities of olivetoric acid, a lichen-derived molecule, in human hepatocellular carcinoma cells

Ali ASLAN

Many lichen secondary metabolites contributed to the field of pharmacology as an active ingredient of different drugs for years. In the present study, we aimed to test the anticancer activity of olivetoric acid (OA), which we isolated from Pseudevernia furfuracea (L.) Zopf in human hepatocellular carcinoma cells (HepG2). In addition, we used non-tumoral human liver cells (THLE2) to test the level of side effects of OA in vitro. For this purpose, cytotoxic (apoptotic and necrotic), oxidant, genotoxic activities and expression levels of apoptotic genes caused by different concentrations (12.5-40 ...More

Article 2021 Fen Fakültesi Rendiconti Lincei. Scienze Fisiche e Naturali32 ( 1 ) 58 Views
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Prophylactic effect of myricetin and apigenin against lipopolysaccharide-induced acute liver injury

Ali ASLAN

Background Liver has an important role in the initiation and progression of multiple organ failure that occurs in sepsis. Many natural active substances can be used to reduce the liver injury caused by sepsis. For this aim, the effects of myricetin and apigenin on mice model of acute liver injury was evaluated in this study. Methods and results Thirty-six mice were randomly divided into six groups as; control, lipopolysaccharide (LPS) (5 mg/kg), LPS myricetin (100 mg/kg), LPS myricetin (200 mg/kg), LPS apigenin (100 mg/kg), and LPS apigenin (200 mg/kg) groups. Myricetin and apigenin were admin ...More

Article 2021 Fen Fakültesi Molecular Biology Reports48 ( 9 ) 47 Views
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