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This article is investigating physio-chemical characteristics in manganese sulfate/acetate and amide compounds including thioacetamide, thiocarbamide, thiosemicarbazide in water at 25 °C by isothermal solubility method. System equilibrium was established within 8-10 hours via continuous stirring. For the determination of manganese ion content and nitrogen ions in thiocarbamide, thioacetamide and thiosemicarbazide compounds, trilonometric, Kjeldahl and Duma methods were used.