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UN Sustainable Development : Good health and well ... ✕Subject Headings : organo-hydrogel ✕
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Good health and well-beingEnsure healthy lives and promote well-being for all ages
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A novel carbohydrate antigen 125 electrochemical sensor based on sweet almond oil organo-hydrogels

Nahit AKTAŞ

Ovarian cancer is a gynecological disease causing many deaths among women around the world. Carbohydrate antigen 125 (CA-125) is a single biomarker known to be a tumor marker of ovarian cancer. CA-125 is widely used to monitor the treatment process, recurrences, and for the detection of ovarian cancer. Herein, organo-hydrogels were prepared in order to detect CA-125 sensitively in serum medium with electrochemical methods. Organo-hydrogels were obtained by the free radical polymerization reaction using agar and glycerol with varying proportions of sweet almond oil using methylene bisacrylamide ...More

Article 2023 Mühendislik Fakültesi Materials Chemistry and Physics298 52 Views
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Agar and Sesame Oil Based Organo-Hydrogels as a Pharmaceutical Excipient in Paracetamol/Carboplatin Release Systems

Nahit AKTAŞ

Organo-hydrogels were synthesized by using free radical polymerization in the emulsion technique, using agar, glycerol, sesame oil, ammonium persulfate as initiator and N,N'-methylene bisacrylamide or glutaraldehyde as crosslinker. Swelling behaviors, blood compatibility, antioxidant and properties of the organo-hydrogels were investigated thoroughly. The highest swelling value was seen in organo-hydrogel synthesized with the N,N'-methylene bisacrylamide crosslinker containing 0.1 ml of sesame oil. Moreover, drug release behaviors of organo-hydrogels were studied as paracetamol and carboplatin ...More

Article 2022 Mühendislik Fakültesi Indian Journal of Pharmaceutical Sciences84 ( 2 ) 41 Views
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Synthesis and characterization of novel organo-hydrogel based agar, glycerol and peppermint oil as a natural drug carrier/release material

Nahit AKTAŞ

The very recent Covid-19 pandemic has made the need to understand biocompatible polymers as support material in drug delivery systems and controlled release clearer, especially for organo-hydrogels. This study aims to synthesize various new polymeric materials called gels, hydrogels, and organo-hydrogels according to the monomer used and to investigate their use as drug release systems. The agar-glycerol (AG) pair was used to synthesize the polymers, N, N, methylene bisacrylamide (MBA, m) and glutaraldehyde (GA, g) were used as cross-linkers and peppermint oil (PmO) was included to obtain the ...More

Article 2021 Mühendislik Fakültesi Materials Science and Engineering: C - Materials For Biological Applications118 107 Views
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Evaluation of poly(agar-co-glycerol-co-castor oil) organo-hydrogel as a controlled release system carrier support material

Nahit AKTAŞ

The aim of this study was to synthesize organo-hydrogels, by using agar, glycerol and different amounts of castor oil in one step, with biocompatible, blood-compatible and antioxidant properties using a new approach to the synthesis of smart polymers. Then, the target was to investigate the applicability of these organo-hydrogels as a drug release system. In the synthesis of organo-hydrogels, crosslinking was achieved with MBA or GA reagent and the redox polymerization technique was applied in the emulsion medium. The swelling behaviors of organo-hydrogels, which were synthesized using differe ...More

Article 2021 Mühendislik Fakültesi Polymer Bulletin79 ( 8 ) 58 Views
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Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material

Nahit AKTAŞ

In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organo-hydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (Wu et al. in J Mol Struct 882:107-115, 2008). Organo-hydrogels, which contained Agar, Glycerol and different amounts of Sweet Almond oil, were synthesized via the free-radical polymerization reaction with emulsion technique using glutaraldehyde or methylene bis acrylamide crosslinkers. Then, the degree of swelling, bond structures, blood compatibility and antioxidant properties of the synthesized organo-hydro ...More

Article 2021 Mühendislik Fakültesi Journal of Polymers and the Environment30 ( 2 ) 133 Views
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Use of Coconut Oil-Based Organo-Hydrogels in Pharmaceutical Applications

Nahit AKTAŞ

In this study, six different organo-hydrogel containing Agar-Glycerol (AG) based Coconut Oil (CnO) were synthesized using different crosslinkers to ensure the controlled release of D-3 Vitamine and 5-Fluorouracil (5-Flu). Synthesized organo-hydrogels were characterized by FT-IR, Afterwards, swelling behaviors were investigated in ethanol, acetone, ethanol/ID water (1:1), acetone /ID water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. Th ...More

Article 2021 Mühendislik Fakültesi Journal of Polymers and the Environment30 ( 2 ) 127 Views
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A garlic oil-based organo-hydrogel for use in pH-sensitive drug release

Nahit AKTAŞ

In this study, six different organo-hydrogels containing agar-glycerol (AG)-based garlic oil (GO) were synthesized using two different crosslinkers (N,N, methylenebisacrylamide (MBA), glutaraldehyde (GA)) to ensure the controlled release of ceftriaxone (Ce) and carboplatin (Cp). Synthesized organo-hydrogels were characterized by FT-IR. Afterward, swelling behaviors were investigated in DI, tap water, ethanol, acetone, ethanol/DI water (1:1), acetone/DI water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels hav ...More

Article 2021 Mühendislik Fakültesi Chemical Papers75 ( 11 ) 75 Views
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Development of onion oil-based organo-hydrogel for drug delivery material

Nahit AKTAŞ

Agar and Glycerol (AG) based Organo-hydrogels containing different cross-linkers and different amounts of Onion Oil were prepared in order to examine the in vitro release of the antibiotic drug Ceftriaxone and the anti-carcinogenic drug Carboplatin. At preparation of the organo-hydrogels was used free radical polymerization technique in the emulsion media. As a control group, Agar-Glycerol (AG) gel and Agar-Glycerol (p (AG-m) and p (AG-g)) hydrogels were synthesized. When balance swelling rates of organo-hydrogels were examined, different swelling behaviors were observed in different solvent e ...More

Article 2021 Mühendislik Fakültesi Journal of Dispersion Science and Technology44 ( 5 ) 69 Views
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Developing poly(Agar-co-Glycerol-co-Thyme Oil) based organo-hydrogels for the controlled drug release applications

Nahit AKTAŞ

In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organohydrogels containing pH-sensitive Agar (A), Glycerol (G), Thyme Oil (TO). The novel organo-hydrogels containing TO were prepared in an emulsion media by the free-radical polymerization and crosslinking reactions among Agar (A), Glycerol (G), TO, N, N, methylenebisacrylamide (MBA) or glutaraldehyde (GA) reagent. Swelling ability (ethanol, acetone, ethanol/ID water (1:1), acetone/ID water (1:1) and gasoline environments and different pH), Fourier Transform Infrared Spectroscopy (FTIR) a ...More

Article 2020 Mühendislik Fakültesi Journal of Drug Delivery Science and Technology60 138 Views
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