New Voltammetric Approach to the Quantitation of Paracetamol in Tablets and Syrup using Chemometric Optimization Technique

Ali Osman SOLAK

A new voltammetric approach was developed for the determination of paracetamol in tablet and syrup samples using chemometric optimization. The method is based on the use of the gold nanoparticles-polyaniline (AuNPs-PA) modified pencil graphite electrode (PGE). Electrode system was fabricated by using the electrochemical reduction of gold on aniline modified pencil electrode to give gold nanoparticles. A 3(3) full factorial design was used to find optimal oxidation conditions of paracetamol on the AuNPs-PA-PGE. The optimal oxidation conditions of drug substance were found as -524 mV for the acc ...Более