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Устойчивое развитие ООН : Крепкое здоровье и б ... ✕Ученые : Ali ASLAN ✕
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Prof. Dr. Ali ASLANFen Fakültesi
Крепкое здоровье и благополучиеОбеспечение здоровой и качественной жизни на всех этапах
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Exploring of the ameliorative effects of Nerium (Nerium oleander L.) ethanolic flower extract in streptozotocin induced diabetic rats via biochemical, histological and molecular aspects

Ali ASLAN

Background: Nerium oleander L. is ethnopharmacologically used for diabetes. Our aim was to investigate the ameliorative effects of ethanolic Nerium flower extract (NFE) in STZ-induced diabetic rats. Methods: Seven random groups including control group, NFE group (50 mg/kg), diabetic group, glibenclamide group and NFE treated groups (25 mg/kg, 75 mg/kg, and 225 mg/kg) were composed of forty-nine rats. Blood glucose level, glycated hemoglobin (HbA1c), insulin level, liver damage parameters and lipid profile parameters were investigated. Antioxidant defense system enzyme activities and reduced gl ...Более

Статья 2023 Fen Fakültesi Molecular Biology Reports50 ( 5 ) 23 Просмотры
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Evaluation of the biological activities of olivetoric acid, a lichen-derived molecule, in human hepatocellular carcinoma cells

Ali ASLAN

Many lichen secondary metabolites contributed to the field of pharmacology as an active ingredient of different drugs for years. In the present study, we aimed to test the anticancer activity of olivetoric acid (OA), which we isolated from Pseudevernia furfuracea (L.) Zopf in human hepatocellular carcinoma cells (HepG2). In addition, we used non-tumoral human liver cells (THLE2) to test the level of side effects of OA in vitro. For this purpose, cytotoxic (apoptotic and necrotic), oxidant, genotoxic activities and expression levels of apoptotic genes caused by different concentrations (12.5-40 ...Более

Статья 2021 Fen Fakültesi Rendiconti Lincei. Scienze Fisiche e Naturali32 ( 1 ) 58 Просмотры
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Cytogenetic and Oxidative Status of Cultured Lymphocytes after Exposure to Extracts from Rhizopogon Mushrooms (Agaricomycetes) In Vitro

Ali ASLAN

In this study, acetone and water extracts obtained from edible mushrooms, Rhizopogon luteolus Fr. and Rh. roseolus (Corda) Th. Fr., containing important bioactive components were used. Total antioxidant capacity (TAC) and total oxidative stress (TOS) levels were examined on human peripheral lymphocyte culture treated with the respective extracts. Levels of genetic damage and cytotoxic effects of the respective extracts on lymphocytes were also tested. In general, when TAC levels of the extracts on cells were examined, a concentration-dependent increase was observed; a negative correlation was ...Более

Статья 2021 Fen Fakültesi International Journal of Medicinal Mushrooms23 ( 3 ) 100 Просмотры
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Potential human health risks of toxic/harmful elements by consumption of Pseudevernia furfuracea

Ali ASLAN

The potential human health risks of some toxic/harmful elements related to the consumption of Pseudevernia furfuracea (L.) Zopf. were investigated. The toxic/harmful elements (cadmium (Cd), chromium (Cr), copper (Cu), lead (Pb), manganese (Mn), nickel (Ni), and zinc (Zn)) were determined in P. furfuracea. According to the analysis result, the maximum (max.) toxic/harmful element value was 62 +/- 3.1 mg/kg for Mn and minimum (min.) value was 0.19 +/- 0.01 mg/kg for Cd. The estimated daily exposure doses (EDEXDs) for men, women and children were dietary (bread) > dietary (tea) > dermal. For diet ...Более

Статья 2021 Fen Fakültesi International Journal of Environmental Health Research32 ( 9 ) 44 Просмотры
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PHENOLIC CONTENT AND BIOLOGICAL ACTIVITIES OF TRAMETES HIRSUTA

Ali ASLAN

Natural mushrooms are one of the important elements of the ecosystem. It has been preferred by people from past to present because of its nutritional and medicinal potentials. In this study, antioxidant, oxidant and antimicrobial potential of Trametes hirsuta (Wulfen) Lloyd has been determined. In addition, phenolic compounds in its fruiting body have been scanned. The antioxidant and oxidant potential was determined using Rel Assay kits. Antimicrobial potential was determined using the agar dilution method. Phenolic contents were scanned on the HPLC device. As a result of the studies, the pre ...Более

Статья 2021 Fen Fakültesi Fresenius Environmental Bulletin30 ( 4A ) 154 Просмотры
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Prophylactic effect of myricetin and apigenin against lipopolysaccharide-induced acute liver injury

Ali ASLAN

Background Liver has an important role in the initiation and progression of multiple organ failure that occurs in sepsis. Many natural active substances can be used to reduce the liver injury caused by sepsis. For this aim, the effects of myricetin and apigenin on mice model of acute liver injury was evaluated in this study. Methods and results Thirty-six mice were randomly divided into six groups as; control, lipopolysaccharide (LPS) (5 mg/kg), LPS myricetin (100 mg/kg), LPS myricetin (200 mg/kg), LPS apigenin (100 mg/kg), and LPS apigenin (200 mg/kg) groups. Myricetin and apigenin were admin ...Более

Статья 2021 Fen Fakültesi Molecular Biology Reports48 ( 9 ) 47 Просмотры
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In vitro evaluation of cytotoxic, oxidative, genotoxic, and apoptotic activities of physodic acid from Pseudevernia furfuracea in HepG2 and THLE2 cells

Ali ASLAN

In the present study, cytotoxic (apoptotic and necrotic), antioxidant, prooxidant, genotoxic, and apoptosis-related genes expression modulatory effects of physodic acid (PA) isolated from Pseudevernia furfuracea on cancerous (HepG2) and healthy (THLE2) human liver cells were evaluated. Cytotoxic effects PA obtained from P. furfuracea on HepG2 and THLE2 cells were tested via MTT and LDH analyses. In order to determine genotoxic effect of PA, 8-OH-dG levels in the cells were measured. In addition, apoptotic or necrotic effects of PA on the hepatic cells were determined by qRT-PCR analysis. Cytot ...Более

Статья 2020 Fen Fakültesi Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology155 ( 6 ) 67 Просмотры
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